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By Norbert Rietbrock, Barry G. Woodcock (auth.), Norbert Rietbrock, Barry G. Woodcock (eds.)

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Additional info for Clinical Pharmacology in the Aged / Klinische Pharmakologie im Alter: Proceedings of the 6th International Symposium on Methods in Clinical Pharmacology, Frankfurt 1985 / Vorträge des 6. Internationalen Symposiums „Methods in Clinical Pharmacology“ Frankf

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The indications from this and other studies is that there may be a reduction in the extent of induction in older subjects although studies to date suffer from the defect that induction is only assessed at one time point and if, as is known to occur in old animals, the induction response is merely slower it could well be missed or under-estimated. Pharmacokinetic studies on the antidepressant zimelidine [12] showed a gross difference between young and elderly in the single dose plasma concentration versus time profiles.

Nevertheless appropriate dose reduction can be recommended in general in old age. Zusammenfassung In einem lebergesunden Patientenkollektiv findet sich nach Ausschlug von Interaktionen (Rauchen, orale Kontrazeptiva und induzierende Begleitmedikation) eine altersabhange Abnahme der hepatischen Elimination von Koffein, Hexobarbital und Lidocain. Wesentlich starkere und den Einflug des Alters iiberdeckende Veranderungen finden sich jedoch bei Lebererkrankungen wie Hepatitis und Leberzirrhose. 41 Grundsatzlich soUte jedoch der Verminderung des oxydativen Arzneimittelmetabolismus im Alter durch eine Dosisanpassung Rechnung getragen werden.

J. Clin. Pharmacol. 5, 407 -13 (1978). [l1J Greenblatt, D. , Allen, M. , Shader, R. : Toxicity of high-dose flurazepam in the elderly. Clinic. Pharmacol. Ther. 21,355-61 (1977). [12J Castleden, C. : The use of hypnotics in elderly patients with impaired liver function. In: Liver and Ageing, Ed. K. Kitani, Elsevier Biomedical Press. P331-346 (1982). [13J Wood, A. J. , Vestal, R. , Wilkinson, G. , Branch, R. , Shand, D. : Effect of ageing and cigarette smoking on antipyrine and indocyanine green elimination.

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