Download Bipolar Depression: Molecular Neurobiology, Clinical by Andreas Marneros (auth.), Carlos A. Zarate, Husseini K. PDF

By Andreas Marneros (auth.), Carlos A. Zarate, Husseini K. Manji (eds.)

Although our wisdom of temper issues usually is increasing progressively, relatively little is understood approximately bipolar melancholy particularly. This publication brings jointly top clinicians and preclinical and scientific researchers to provide the main updated information regarding the prognosis, remedy, and examine surrounding bipolar depression.

Early chapters offer beneficial diagnostic info, and overview the direction, end result, and genetics of this hugely heritable situation, permitting clinicians to tell apart among some of the temper problems. The booklet deals a radical and detailed evaluation of the neurobiology of the sickness, together with what's recognized from fresh neuroimaging paintings. a number of chapters delineate the therapy of bipolar melancholy in unique populations reminiscent of childrens and pregnant ladies, and one other bankruptcy addresses the actual problems with suicide, concentrating on the necessity for review in the course of either acute and upkeep therapy with interventions applicable to a patient's indicators and heritage. ultimately, the e-book covers acute and long term therapy recommendations for bipolar melancholy, together with either conventional and novel therapeutics for the affliction, in addition to non-pharmacological remedies.


This e-book has assembled a largely revered staff of preclinical and scientific researchers who carry their services to endure upon this disease. It bargains researchers, clinicians, and postgraduate scholars key insights into this devastating disorder.

Show description

Read Online or Download Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy PDF

Best clinical books

Clinical and Forensic Applications of Capillary Electrophoresis

Simply because capillary electrophoresis (CE) is using the automation of handbook and semi-manual thoughts, conserves invaluable samples, and minimizes using damaging natural chemical compounds, it constitutes a strong new method for the scientific laboratory. In scientific and Forensic functions of Capillary Electrophoresis, John R.

Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

Even if our wisdom of temper issues generally is increasing progressively, relatively little is understood approximately bipolar melancholy particularly. This e-book brings jointly best clinicians and preclinical and medical researchers to supply the main updated information regarding the analysis, remedy, and examine surrounding bipolar melancholy.

Progress in Catheter Ablation: Clinical Application of New Mapping and Ablation Technology

Catheter ablation is largely accredited as a good and secure kind of treatment for cardiac arrhythmia. routinely this healing technique is taken into account because the first line of remedy if no longer the final word therapy of selection. With using radiofrequency (RF) modality; which has revolutionized the know-how from a barotraumatic, in all likelihood injurious strategy utilizing excessive­ voltage, direct-current (DC) surprise to a secure and comparatively painless one; catheter ablation technique now consists of a really low chance and is very powerful for specific sorts of arrhythmia.

The Economics of Obesity: Poverty, Income Inequality and Health

Offering a desirable perception into the criteria that impact person offerings concerning consuming behavior, vitamin and different behavioral styles proper to weight problems, this booklet bargains a brand new standpoint in regards to the dating of weight problems to poverty and inequality. The authors discover a special socioeconomic version that is helping construct the framework to appreciate the motives of weight problems and its relation to health and wellbeing, technological know-how, and economics.

Additional info for Bipolar Depression: Molecular Neurobiology, Clinical Diagnosis and Pharmacotherapy

Example text

Of the set of more than 20 clinical features, several were suggested as possibly more likely in those with BPD, including worthlessness, psychotic features, social withdrawal, hyperphagia and hypersomnia, and mood lability. Co-morbid anxiety states and alcohol use were suggested as overrepresented, as was a family history of BPD. Mitchell and colleagues [12] examined some 40 candidate markers of bipolarity and proposed a ‘probabilistic’ model for considering a diagnosis of bipolar I depression in an individual experiencing a major depressive episode with no clear prior episodes of mania.

The recurrence risk of bipolar disorders is about twice that of unipolar depression. Furthermore, recovery is more frequent among unipolar than among bipolar patients, although 5-year remission rates were found to be independent of the number of episodes [16]. There appears to be a constant risk of recurrence over the life-span up to the age of 70 or more, even 30 to 40 years after onset [20]. The long-term course usually causes significant handicaps and problems in the lives of patients, and in many cases leads to disability [21].

B. Parker and K. Fletcher subjects), and is categorical in positioning ‘psychotic features’ as differentiating subtypes of BPD. The model is also heuristic. It presupposes that those with BPD II oscillate within a narrower band than those with BPD I. While we had previously produced data [7] indicating that those with BPD were highly likely to experience melancholic or psychotic depression when depressed, the isomer model allows more refined hypotheses. It suggests that those with BPD II oscillate between non-psychotic hypomanic and melancholic episodes, while those with BPD I experience psychotic manic episodes and have either psychotic or melancholic episodes when depressed.

Download PDF sample

Rated 4.87 of 5 – based on 38 votes