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By Professor Dr. med. Helmut Löffler, Professor Dr. med. Johann Rastetter, Professor Dr. med. Dr. phil. T. Haferlach (auth.)

This sixth variation of the atlas has built-in the 2001 WHO type and made use of figures and outlines to record lately defined sorts of leukemia and lymphoma. The latter contain leukemias of dendritic cells, infrequent lymphomas and chronic polyclonal B lymphocytosis, which takes a distinct position within the classification.

The quantity covers the entire microscopic equipment in hematology that shape the root of prognosis in addition to the result of glossy immunologic, cytogenetic and molecular-genetic research. certain emphasis is put on the cytogenetic and molecular-genetic characterization of organic entities that will shape the root for cutting edge therapies.

Normal effects and pathological findings are in comparison, and a few of the findings made in the course of remedy are depicted. All in all of the Atlas of medical Hematology represents an entire and priceless reference paintings which could be found in each hematologic and oncologic division in addition to in medical laboratories for on-line diagnostics and medical research.

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3) IV 32 Chapter IV · Blood and Bone Marrow Fig. 5 a – d IV a b c d 33 4 · Individual Cells Fig. 5 e – h e f g h IV 34 Chapter IV · Blood and Bone Marrow Erythrocytes (Fig. 6 a) containing nuclear remnants in the form of Howell-Jolly bodies, which are observed after splenectomy and in cases of splenic atrophy. Chromatin dust, like the Howell-Jolly bodies, consist of nuclear remnants. IV Target cells (Mexican hat cells) (Fig. 6 b) are distinguished from anulocytes by the deeper staining of their central zone and peripheral rim.

Ziehl-Neelsen stain: 1. Fix the specimen with heat. 2. Cover with 10 % carbolfuchsin and heat to steaming 3 times; stain for 3 min. 3. Decolorize in 3 changes of acid alcohol for 3 min. 4. Wash with water. 5. Counterstain with dilute methylene blue solution for 3 min. 6. Wash with water and dry between sheets of blotting paper. Illustrations III Overview of Cells in the Blood, Bone Marrow, and Lymph Nodes 23 IV Blood and Bone Marrow 27 V Lymph Nodes and Spleen 293 VI Tumor Aspirates from Bone Marrow Involved by Metastatic Disease 385 VII Blood Parasites and Other Principal Causative Organisms of Tropical Disease 399 23 Overview of Cells in the Blood, Bone Marrow, and Lymph Nodes III 24 III Chapter III · Overview of Cells in the Blood, Bone Marrow, and Lymph Nodes Figure 1 presents an overview of the various cells of hematopoiesis.

4 a – d a b c d IV 30 Chapter IV · Blood and Bone Marrow Fig. 4 e – f IV e f 31 4 · Individual Cells Erythrocytes (Figs. 5 a – h, 6 a – i) The morphologic evaluation of erythrocytes is based on the following criteria: – Size – Shape – Hemoglobin: concentration, distribution – Stainability – Distribution in the smear – Inclusions Normal erythrocytes (Fig. 5 a) (diam. 7 – 8 lm). Hypochromic erythrocytes (Fig. 5 b) in iron deficiency anemia. The cells, which have normal diameters, are conspicuous for their paucity of hemoglobin, which may form only a thin peripheral rim (anulocytes).

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