Download Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is key to homeostasis within the respiration tract. against this, while irregular, mucus contributes considerably to the pathophysiology of a couple of critical bronchial ailments, together with bronchial asthma, continual bronchitis and cystic fibrosis. This quantity offers large ranging and in-depth assurance of the medical and scientific points of airway mucus. It commences with introductory chapters which tackle the biochemical and molecular organic foundation of airway mucus and maintains with finished assurance of a few of the physiological and rheological elements of respiration secretions. The medical facets of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory illnesses of the airway. the quantity concludes with a dialogue of the healing features of the subject, either when it comes to the prospective methods to the therapy of mucus hypersecretion and the interplay of those medications with airway mucus. Written by way of top specialists within the box, every one contribution presents a entire overview of its specific topic. Reflecting the newest advances during this vital sector of respiration examine, this quantity might be of significant curiosity to scientists and clinicians operating within the box of airway secretions and similar areas.

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Extra info for Airway Mucus: Basic Mechanisms and Clinical Perspectives

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Thus, the mucus gel in chronic bronchitis may have an increased contribution of gland mucins as opposed to those from the goblet cells in the surface epithelium, and the increased acidity observed by histological investigation might thus have been obscured because mucins from the same cellular sources were not compared. 2. Gene Products The three mucins MUC5AC, MUCX and MUCY are present in varying amounts in sputa from asthmatic, chronic bronchitic and cystic fibrotic airways (Figure 4). At present only a limited number of samples have been analysed, and it is not yet clear whether the level of anyone of them can be related to the pathological process.

48-50]) with, for example, as many as 88 different oligosaccharide structures identified so far from the mucins of a single individual [51]. It is clear, considering the number of different apomucins expressed in the respiratory tract, that these studies were probably performed on mixtures of mucins rather than on distinct populations. Thus, 24 D. J. Thornton et al. DQ Core region r- , ~~... ~"-. ~ /GaINAC Ct-O-ser/thr -

Thornton et al. 53. Scharfmann A, Lamblin G, Roussel P (1995) Interactions between human respiratory mucins and pathogens. Biochem Soc Trans 23: 836-839. 54. Lo-Guidice J-M, Wieruszeski J-M, Lemoine J, Verbert A, Roussel P, Lamblin G (1994) Sialylation and sulfation of the carbohydrate chains in respiratory mucins from a patient with cystic fibrosis. J Bioi Chem 269: 18794-18813. 55. Dekker J, Strous GJ (1990) Covalent oligomerization of rat gastric mucin occurs in the rough ER, is N-glycosylation dependent, and precedes initial O-glycosylation.

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