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Rodstein M, Wolloch L, Gubner RS. Mortality study of the significance of extrasystoles in an insured population. Circulation 1971;44:617-25. Saikawa T, Niwa H, Ito M, et al. The effect of propafenone on premature ventricular contractions (PVC): an analysis based on heart rate dependency of PVCs. Jpn Heart J 2001;42:701-11. Sapoznikov D, Luria MH, Gotsman MS. Changes in sinus RR interval patterns preceding ventricular ectopic beats: assessment with rate enhancement and dynamic heart rate trends.

032). (Data not shown) 4. Discussion The methods used in the Mexico City Diabetes Study meet the accepted international criteria in terms of study protocol, diagnostic algorithms, and particularly electrocardiographic interpretations. [11] The ECGs were interpreted without disclosure of clinical or laboratory data, in a reference center recognized as a gold standard for this procedure. A rigorous quality control procedure was followed along the study. 277 - - Models were run by using generalized estimating equations with family normal and identity link.

004). Considering the presence of PVCs during exercise and/or recovery did not affect our results. All five athletes with at least one PVC on a routine screening ECG as part of the annual physical exams had normal echocardiograms and no clinical manifestations of heart disease. Thus, we concluded that PVCs on a resting ECG are a significant and independent predictor of all-cause and cardiovascular mortality. Increased heart rate predicts mortality in patients with and without PVCs and the combination dramatically increases mortality.

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